1Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States
Myelin,
a thin layer of sheath-like cell, provides an important role in protecting
nerve axon and accelerating neural impulse transmission. Myelin water fraction
(MWF) mapping has been recently proposed for assessing myelin content in-vivo. One
quantitative MR method called mcDESPOT has shown promising results for
assessing myelin content. However, this method is lack of consideration of magnetization
transfer (MT) effect leading to the complication of interpretation for MWF
values. In this study, we proposed a method called mcRISE to account for MT effect
and investigate the feasibility of assessing myelin content with MT-insensitive
MWF as well as additional MT parameters.
