Abstract #1275

Analyzing Myelin Water Fraction using mcRISE

Fang Liu¹, Andrew Alexander², and Alexey Samsonov¹

¹Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Myelin, a thin layer of sheath-like cell, provides an important role in protecting nerve axon and accelerating neural impulse transmission. Myelin water fraction (MWF) mapping has been recently proposed for assessing myelin content in-vivo. One quantitative MR method called mcDESPOT has shown promising results for assessing myelin content. However, this method is lack of consideration of magnetization transfer (MT) effect leading to the complication of interpretation for MWF values. In this study, we proposed a method called mcRISE to account for MT effect and investigate the feasibility of assessing myelin content with MT-insensitive MWF as well as additional MT parameters.

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