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Abstract #1276

Quantification of Myelin by Solid-State MRI of the Lipid Matrix Protons

Cheng Li1, Alan C. Seifert2, Suzanne L. Wehrli3, and Felix W. Wehrli1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3NMR Core Facility, Children’s Hospital of Philadelphia, Philadelphia, PA, United States

Myelin is a lamellar liquid crystal consisting of a variety of phospholipids and cholesterol, water and proteins. So far quantitative information on myelin density has been obtained primarily indirectly via myelin water quantification or quantitative magnetization transfer. Here, we examined 3D UTE and ZTE methods at 400 MHz demonstrating the feasibility of MRI quantification of reconstituted myelin suspended in D2O as well as of myelin in lamb spinal cord in situ. Results show the magnitude signal amplitude to be linearly correlated with actual myelin content, allowing estimation to be made of myelin fraction in neural tissues.

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