Abstract #1277

Quantitative Estimates of Myelin Volume Fraction from T2 and Magnetization Transfer

Kathryn L West^1,2, Nathaniel D Kelm^1,2, Daniel F Gochberg^2,3, Robert P Carson⁴, Kevin C Ess⁴, and Mark D Does^1,2

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ⁴Neurology, Vanderbilt University, Nashville, TN, United States

Multiexponential T₂ and quantitative magnetization transfer experiments provide quantitative measures of myelin water fraction (MWF) and bound pool fraction (BPF), respectively. These measures are known to correlate with myelin content in white matter; however discrepancies between the two have been shown. We display that by correcting for all proton pools contributing to MWF and BPF in white matter, we are able to show similar absolute measures of myelin content from MWF and BPF that are nearly equal to each other and close to myelin content measured by quantitative histology.

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