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Abstract #1281

Using T1 and Quantitative Magnetization Transfer to Monitor Tissue Myelin Content in the Lysolecithin Model of Multiple Sclerosis

Raveena Dhaliwal1,2,3, Daniel J. Korchinski1,2,3, Samuel K. Jensen1,2, V. Wee Yong1,2, and Jeff F. Dunn1,2,3

1Neuroscience, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, Calgary, AB, Canada, 3Radiology, University of Calgary, Calgary, AB, Canada

Multiple Sclerosis requires treatments that stimulate remyelination and reduce demyelination. Currently, both T1 and the quantitative magnetization transfer parameter bound pool fraction (f) have been found to correlate strongly with myelin content but little is known about the sensitivity of these techniques at different signal to noise ratios. This work demonstrates that T1 is highly sensitive to changes in myelin content but f can miss significant differences in tissue myelin content at a standard signal to noise. MS treatments should be developed using a multi-modal approach that combines techniques with high sensitivity (T1) and those that have high specificity (f).

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