Abstract #1280

Water content changes in new multiple sclerosis lesions have minimal effect on myelin water fraction

Irene Vavasour¹, Kimberley Chang², Anna Combes³, Sandra Meyers⁴, Shannon Kolind², Alexander Rauscher⁵, David Li¹, Anthony Traboulsee², Alex MacKay^1,4, and Cornelia Laule^1,6

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²Medicine, University of British Columbia, Vancouver, BC, Canada, ³Neuroimaging, King's College London, London, United Kingdom, ⁴Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁵Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁶Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Myelin water fraction (MWF) is a useful technique for measuring myelination changes in vivo. However, since MWF is the fraction of myelin water over the total water, changes in water content (WC) can influence this measurement. This is particularly relevant in new multiple sclerosis (MS) lesions which may have demyelination but also show significant increases in WC at first appearance that resolve at later times. We compared MWF and myelin water content (MWC=MWF×WC) in new MS lesions. Similar patterns of change were seen with both MWF and MWC indicating that changes in WC had minimal effect on the MWF.

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