Abstract #1279

Clinical Feasibility of Myelin Water Fraction (MWF) Imaging Based on 3D Non-selective GRASE Sequence

Dushyant Kumar^1,2, Patrick Borchert¹, Jens Fiehler¹, Susanne Siemonsen^1,2, and Jan Sedlacik¹

¹Dept. of Diagnostic and Interventional Radiology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, ²Institute of Neuroimmunology and Multiple Sclerosis, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

Problem: The clinical utility of myelin imaging based on “gold standard” multi echo spin echo (MESE) T2 relaxometry is currently impeded due to requirement of high SNR and need to account for contributions from stimulated pathways. We compare faster GRASE based myelin quantification against those from MESE. Methods: 3D non-selective GRASE and MESE were optimized. Implemented post processing method combines T2-decay model based extended phase graph with spatial regularization framework to improve on noise robustness and accurately account for B1-error. Results & Conclusions: Results demonstrate good consistency between MWF-maps from both sequences, except in left part of frontal brain.

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