Abstract #1283

Direct phase imaging of myelin: a validation study using ultrashort echo time (UTE) sequence and myelin phantoms

Qun He^1,2, Vipul Sheth¹, Hongda Shao¹, Jun Chen¹, Graeme Bydder¹, and Jiang Du¹

¹University of California, San Diego, San Diego, CA, United States, ²Ningbo Jansen NMR Technology Co., Ltd., Cixi, Zhejiang, China, People's Republic of

Phase images have been a valuable source of contrast in applications such as venography and for depicting gray-white matter differences with high contrast in high field MR imaging. Phase differences evolve during typical TEs of 10 - 30ms in brain studies. It has been uncertain whether it would be possible to detect signal and obtain phase maps from ultrashort non-water protons in myelin which have typical mean T₂s of 0.2 - 0.5 ms. In this study single and bicomponent T₂* were measured in bovine myelin lipid, brain extract, and myelin basic proton and synthetic myelin and high quality phase maps were produced in each case.

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