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Abstract #1284

Direct IR-UTE imaging of myelin in healthy volunteers: the effect of T1 variation

Rong Luo1, Soorena Azam ZAnganeh1, Hongda Shao1, Jun Chen1, Graeme Bydder1, and Jiang Du1

1Radiology, University of California, San Diego, San Diego, CA, United States

MS is a disease that relatively specifically affects myelin which is invisible with conventional sequences. Adiabatic inversion recovery prepared ultrashort echo time (IR-UTE) sequences have been proposed to directly image myelin protons and suppress the long T2 water signal by adiabatic inversion and signal nulling. However, water signal contamination is a major challenge. T1 variation in long T2 white matter, and thus imperfect choice of TI is a potential source of error in direct myelin imaging. We aimed to investigate the T1 variation in long T2 white matter in volunteers, and the effects of this on IR-UTE imaging of myelin.

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