Abstract #1285

RAFF4 MRI in detection of demyelinating lesions induced by lysophosphatidyl choline injections in rat

Lauri J Lehto^1,2, Alejandra Sierra¹, Aloma Albors¹, Shalom Michaeli², Antti Nurmi³, Laura Tolppanen³, Lynn E Eberly⁴, Silvia Mangia², and Olli Gröhn^1,2

¹A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ³Charles River Laboratories, Kuopio, Finland, ⁴Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States

An MRI contrast sensitive to demyelination would be invaluable in assessing a multitude of neurodegenerative diseases. Here, we demonstrate the benefits of a novel rotating frame method entitled Relaxation Along a Fictitious Field in the rotating frame of rank n (RAFFn) in detection of demyelinating lesions induced by lysophosphatidyl choline (LPC) injections in the rat corpus callosum (CC) and dorsal tegmental tract (DTG). RAFFn performed better than magnetization transfer in CC and DTG, and clearly outperformed diffusion tensor imaging in DTG, an area with heterogeneous fiber orientation distribution. Our results demonstrate high potential of RAFFn for imaging demyelinating lesions.

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