Abstract #1290

New insight in perivenular lesion formation in multiple sclerosis on weekly susceptibility weighted images

Simon Mure¹, Charles Guttmann², Thomas Grenier¹, Hugues Benoit-Cattin¹, and François Cotton³

¹CREATIS, Villeurbanne cedex, France, ²Center for Neurological Imaging, Brigham and Women's Hospital, Boston, MA, United States, ³CREATIS - HCL, Villeurbanne cedex, France

In this paper, we take advantage of a unique longitudinal MRI dataset acquired at weekly intervals on untreated multiple sclerosis patients. We study the signal dynamics of relapsing-remitting multiple sclerosis lesions on SWI MRI and show, thanks to an unsupervised spatiotemporal clustering algorithm, that specific signal intensity behaviors exist between the veins and the lesions that are synchronous with contrast enhancement on gadolinium-enhanced T1-weighted MRI. Our study shows that vein narrowing depicted on SWI is an early event that appears to precede blood-brain barrier disruption signified by contrast-enhancement.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.