Abstract #1295

Focal cerebellar pathology in early relapsing-remitting multiple sclerosis patients: a MP2RAGE study at 3T and 7T MRI

Mário João Fartaria^1,2, Guillaume Bonnier^1,2, Tobias Kober^1,2,3, Kieran O'Brien^4,5, Alexis Roche^1,2,3, Bénédicte Maréchal^1,2,3, Reto Meuli², Jean-Philippe Thiran^2,3, Gunnar Krueger⁶, Meritxell Bach Cuadra^2,3,7, and Cristina Granziera^1,7,8,9

¹Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ³Signal Processing Laboratory (LTS 5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia, ⁵Siemens Healthcare Pty Ltd., Brisbane, Queensland, Australia, ⁶Siemens Medical Solutions USA, Inc., Boston, Switzerland, ⁷Signal Processing Core, Centre d'Imagerie BioMédicale (CIBM), Lausanne, Switzerland, ⁸Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ⁹Neuroimmunology Unit, Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

In this work, we assessed the sensitivity of MP2RAGE at 7T MRI to detect focal cerebellar pathology, both in grey and white matter. To do this, we compared cerebellar lesion count in 7T and 3T MP2RAGE images in a cohort of MS patients. Lesion detection rate at 7T MRI was higher than the one at 3T, yet the total lesion volume was comparable at different field strengths. Lesion volumes calculated on 7T MP2RAGE images showed higher correlations with clinical scores than the ones at 3T, pointing at a clinical value of 7T MRI for complex regions such as cerebellum.

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