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Abstract #1295

Focal cerebellar pathology in early relapsing-remitting multiple sclerosis patients: a MP2RAGE study at 3T and 7T MRI

Mário João Fartaria1,2, Guillaume Bonnier1,2, Tobias Kober1,2,3, Kieran O'Brien4,5, Alexis Roche1,2,3, Bénédicte Maréchal1,2,3, Reto Meuli2, Jean-Philippe Thiran2,3, Gunnar Krueger6, Meritxell Bach Cuadra2,3,7, and Cristina Granziera1,7,8,9

1Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland, 2Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3Signal Processing Laboratory (LTS 5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia, 5Siemens Healthcare Pty Ltd., Brisbane, Queensland, Australia, 6Siemens Medical Solutions USA, Inc., Boston, Switzerland, 7Signal Processing Core, Centre d'Imagerie BioMédicale (CIBM), Lausanne, Switzerland, 8Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 9Neuroimmunology Unit, Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

In this work, we assessed the sensitivity of MP2RAGE at 7T MRI to detect focal cerebellar pathology, both in grey and white matter. To do this, we compared cerebellar lesion count in 7T and 3T MP2RAGE images in a cohort of MS patients. Lesion detection rate at 7T MRI was higher than the one at 3T, yet the total lesion volume was comparable at different field strengths. Lesion volumes calculated on 7T MP2RAGE images showed higher correlations with clinical scores than the ones at 3T, pointing at a clinical value of 7T MRI for complex regions such as cerebellum.

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