Abstract #1294

Assessment of whole brain blood flow changes in multiple sclerosis: phase contrast MRI versus ASL

Yulin Ge¹, Olga Marshall¹, Ilya Kister¹, Jean-Christophe Brisset¹, Louise Pape¹, Jacqueline Smith¹, and Robert I Grossman¹

¹Radiology, New York University School of Medicine, New York City, NY, United States

Cerebral blood flow (CBF) is an important characteristic of the brain since it reflects the availability of blood to enable healthy neuronal function. Previous studies in multiple sclerosis (MS) have shown regional hemodynamic changes indicating a state of both increased or decreased perfusion, which may reflect underlying neuroinflammatory activity and impaired vascular perfusion of the disease, respectively. However, it is still unclear how the whole brain blood supply or blood flow changes in MS. This study was to investigate whether global CBF levels are effected in MS compared to controls, while evaluating with two different imaging techniques to confirm the findings.

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