Abstract #1293

T1ρ MRI Demonstrates Increased Contrast-to-Noise-Ratio in MS Lesions Compared to T2

Jay V Gonyea¹, Richard Watts¹, Angela Applebee², Trevor Andrews^1,3, Scott Hipko¹, Joshua P Nickerson¹, Lindsay Thornton⁴, and Christopher G Filippi⁵

¹Radiology-MRI Center for Biomedical Imaging, University of Vermont College of Medicine, Burlington, VT, United States, ²Neurological Sciences, University of Vermont College of Medicine, Burlington, VT, United States, ³Philips Health Tech, Cleveland, OH, United States, ⁴Radiology, University of Florida, Gainesville, FL, United States, ⁵Radiology, North Shore University Hospital-Long Island Jewish, New York, NY, United States

Quantitative MRI measures such as T₂are limited in their ability of staging MS progression. T_1ρmay be sensitive to low-frequency chemical exchange between proteins and extracellular water. A 3D TSE with whole-brain coverage, spin-lock times of 0, 20, 40, 60, 80, and 100 ms spin-lock times was acquired at 500 Hz. We found that T_1ρ provides better contrast-to-noise-ratio (CNR) than T₂.

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