Abstract #1292

Edema-Correction is Essential for Monitoring Brain Atrophy with BPF

Marcel Warntjes^1,2, Anders Tisell^1,3, Irene Håkansson⁴, and Peter Lundberg¹

¹Center for Medical Imaging Science and Visualization, Linköping, Sweden, ²SyntheticMR AB, Linköping, Sweden, ³Department of Medical and Health Sciences, Radiation Physics, Linköping, Sweden, ⁴Department of Clinical and Experimental Medicine, Neurology, Linköping, Sweden

The rate of brain atrophy in neuro-degenerative diseases is monitored using the brain parenchymal fraction (BPF, the ratio of brain volume and intracranial volume). The true atrophy, however, may be obscured by the simultaneous brain swelling due to inflammatory processes, disease activity and medication. Measurement of the average relaxation rates and proton density of the brain allows correction for the presence of edemic water. The edema-corrected BPF showed a higher rate of atrophy, 0.495%/year (p = 0.003), in comparison to the uncorrected BPF, 0.175%/year (p = 0.12), in a group of early-onset Multiple Sclerosis patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.