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Abstract #1297

Exploring Sodium MRI Contrast Beyond Concentration in Multiple Sclerosis Lesions

Robert Stobbe1, Penny Smyth2, Roxane Billey2, Leah White2, Fabrizio Giuliani2, Derek Emery3, and Christian Beaulieu1

1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Neurology, University of Alberta, Edmonton, AB, Canada, 3Radiology, University of Alberta, Edmonton, AB, Canada

Two different relaxation-weighted 23Na sequences were compared to density-weighted 23Na imaging in the context of multiple sclerosis (MS) and the lesion contrast produced by each sequence was significantly different, thus identifying the presence of substantial 23Na relaxation change. Given that macromolecular density and structure directly influence the electric field gradients driving orientation of the nuclear electric quadrupole moment and 23Na relaxation, exploration of 23Na relaxation change may help in the assessment of MS including axonal loss and demyelination. The use of relaxation-weighted sequences and their relative combination to eliminate sodium concentration dependence is a starting point for 23Na relaxation exploration.

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