Abstract #1297

Exploring Sodium MRI Contrast Beyond Concentration in Multiple Sclerosis Lesions

Robert Stobbe¹, Penny Smyth², Roxane Billey², Leah White², Fabrizio Giuliani², Derek Emery³, and Christian Beaulieu¹

¹Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, ²Neurology, University of Alberta, Edmonton, AB, Canada, ³Radiology, University of Alberta, Edmonton, AB, Canada

Two different relaxation-weighted ²³Na sequences were compared to density-weighted ²³Na imaging in the context of multiple sclerosis (MS) and the lesion contrast produced by each sequence was significantly different, thus identifying the presence of substantial ²³Na relaxation change. Given that macromolecular density and structure directly influence the electric field gradients driving orientation of the nuclear electric quadrupole moment and ²³Na relaxation, exploration of ²³Na relaxation change may help in the assessment of MS including axonal loss and demyelination. The use of relaxation-weighted sequences and their relative combination to eliminate sodium concentration dependence is a starting point for ²³Na relaxation exploration.

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