Abstract #1298

MRI detects the effects of demyelination and remyelination on hippocampal structure and function

Harsha Battapady¹, Jacqueline Chen¹, and Bruce D Trapp¹

¹Neurosciences, Cleveland Clinic, Cleveland, OH, United States

Multiple sclerosis (MS) features demyelination of the brain and spinal cord, resulting in impaired and eventual loss of neuronal function. Approximately 65% of MS patients experience cognitive impairment and memory dysfunction. Postmortem analyses reveal hippocampal demyelination and glutamate receptor loss in MS patients, suggesting impaired synaptic function in this brain region critical for memory and learning. Using a mouse model of reversible demyelination, we demonstrate that MRI can detect the loss and restoration of myelin and neuronal function in the hippocampus. Our results suggest that MRI is a powerful pre-clinical tool for testing neuroprotective and reparative therapies targeting the hippocampus.

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