Abstract #1300

Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders

Paola Valsasina¹, Maria Assunta Rocca¹, Filippo Savoldi¹, Marta Radaelli², Paolo Preziosa¹, Giancarlo Comi², Andrea Falini³, and Massimo Filippi¹

¹Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²Department of Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ³Department of Neuroradiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

This study gives a comprehensive description of sensory and motor resting state functional connectivity abnormalities in patients with neuromyelitis optica spectrum disorders (NMOSD) fulfilling the new 2015 diagnostic criteria. Functional connectivity abnormalities found in these patients were compared with isolated optic neuritis and myelitis. Our results suggest different mechanisms of brain reorganization in NMOSD vs isolated optic neuritis and myelitis, with a more evident cross-modal plasticity between sensory systems in NMOSD patients. This result might help to better characterize the different pathophysiological mechanisms occurring in these conditions.

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