Abstract #1301

Correlation of transcallosal motor network resting state connectivity with motor performance after 12 months of Fingolimod treatment

Pallab K Bhattacharyya¹, Robert Fox², Jian Lin¹, Ken Sakaie¹, and Mark Lowe¹

¹Imaging Institute, Cleveland Clnic, Cleveland, OH, United States, ²Neurological Institure, Cleveland Clnic, Cleveland, OH, United States

Resting state functional connectivity (fcMRI) between left and right primary motor cortices in MS patients on Fingolimod treatment was studied at baseline (just before the start of the treatment), 6 months and 12 months after start of treatment. Since such fcMRI metric has been previously reported to be reduced, changes in fcMRI over every 6 months interval were correlated with changes in clinical score as measured by 9 hole peg test duing the treatment course. A significant difference in the correlation was observed between dominant and non-dominant hand performance in between 6 and 12 months.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.