Correlation of transcallosal motor network resting state connectivity with motor performance after 12 months of Fingolimod treatment
Pallab K Bhattacharyya1, Robert Fox2, Jian Lin1, Ken Sakaie1, and Mark Lowe1
1Imaging Institute, Cleveland Clnic, Cleveland, OH, United States, 2Neurological Institure, Cleveland Clnic, Cleveland, OH, United States
Resting state functional connectivity (fcMRI) between left and right primary motor cortices in MS patients on Fingolimod treatment was studied at baseline (just before the start of the treatment), 6 months and 12 months after start of treatment. Since such fcMRI metric has been previously reported to be reduced, changes in fcMRI over every 6 months interval were correlated with changes in clinical score as measured by 9 hole peg test duing the treatment course. A significant difference in the correlation was observed between dominant and non-dominant hand performance in between 6 and 12 months.
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