Abstract #1302

Contribution of cortical lesion volume detected with 7T MRI to cortical thinning, thalamic and callosal atrophy in multiple sclerosis

Tobias Granberg^1,2,3,4, Russell Ouellette^1,2, Constantina Andrada Treaba^1,2, Celine Louapre^1,2, Sindhuja T Govindarajan^1,2, Costanza Giannì^1,2, Elena Herranz^1,2, Revere P Kinkel⁵, and Caterina Mainero^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Radiology, Karolinska University Hospital, Stockholm, Sweden, ⁵Department of Neurosciences, University of California, San Diego, CA, United States

Grey matter pathology contributes to disability in multiple sclerosis (MS), but in vivo sensitivity for cortical lesions is low with conventional MRI. The role of cortical pathology in the dynamic atrophy processes in MS is, therefore, uncertain. Using 7T MRI and longitudinal 3T imaging (mean follow-up 1.9 years), we showed, in a small MS cohort, that cortical lesion volumes at follow-up correlated with cortical thinning in areas known to be predilection sites for cortical demyelination in MS, while thalamic atrophy was more strongly associated with white matter lesions. No effect of cortical lesions was found on corpus callosal atrophy.

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