Abstract #1307

Disruption of functional connectivity of M1 and cerebellum in Multiple sclerosis: a long-range functional dysconnection?

Adnan A.S. Alahmadi^1,2, Carmen Tur¹, Matteo Pardini^1,3, Peter Zeidman⁴, Rebecca S. Samson¹, Egidio D'Angelo^5,6, Ahmed T. Toosy^1,7, Karl J. Friston⁴, and Claudia Angela Michela Gandini Wheeler-Kingshott^1,6

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom, ²Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, ³Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy, ⁴Wellcome Centre for Imaging Neuroscience, UCL, Institute of Neurology, London, United Kingdom, ⁵Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ⁶Brain Connectivity Center, C.Mondino National Neurological Institute, Pavia, Italy, Pavia, Italy, ⁷NMR Research Unit, Department of Brain Repair and Rehabilitation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom

This study investigated changes in functional and effective connectivity with M1 and anterior cerebellum using psychophysiological interaction (PPI) and resting-state fMRI (rsfMRI), applied to a motor task fMRI dataset in healthy subjects and multiple sclerosis (MS) patients. Results show that M1 in MS patients has reduced long-range connectivity to the contra-lateral hemisphere and the cerebellum and vice versa. Furthermore, MS patients lose visuo-motor integration with parietal areas. This is in contrast to rsfMRI functional connectivity, where connectivity of M1 to areas identified by the PPI network is increased. Results indicate a task-specific disconnection reflecting increased disability, associated also with low frequency maladaptive increased rsfMRI connectivity.

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