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Abstract #1313

In vivo white matter development of Fmr1 knockout mice

Da Shi1, Jiachen Zhuo1, Su Xu1, Mary C. McKenna2, and Rao P. Gullapalli1

1Diagnostic Radiology, University of Maryland Baltimore, Baltimore, MD, United States, 2Department of Pediatrics, University of Maryland Baltimore, Baltimore, MD, United States

Fragile X syndrome is the most common genetic cause of autism and is modeled with the Fmr1 knockout mouse. To investigate recent report of myelination delay in Fragile X, this study used translational imaging techniques including T2 mapping and magnetization transfer imaging to determine myelination changes in the developing Fmr1 knockout mouse. Age-related trajectory changes in regional white matter development were observed between the genotypes and may provide insights into the pathophysiology of Fragile X.

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