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Abstract #1314

Induction of Experimental Autoimmune Encephalomyelitis (EAE) in cynomolgus monkey: a valuable model of auto-immune demyelinating diseases

Julien Flament1,2, Claire-Maëlle Fovet1,3, Lev Stimmer1,3, Philippe Hantraye1,2,4, and Ché Serguera1,2

1CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France, 2INSERM UMS 27, Fontenay-aux-Roses, France, 3INSERM UMR 1169, Fontenay-aux-Roses, France, 4CNRS Université Paris-Saclay UMR 9199, Fontenay-aux-Roses, France

Acquired demyelinating diseases are a major cause of neurological disabilities. If Experimental Autoimmune Encephalomyelitis (EAE) model has been widely used in rodents, it does not recapitulate disease variability observed in humans. We propose for the first time a primate model of EAE without immunomodulatory treatment in Macaca fascicularis which exhibited a more developed immune system than rodents. All monkeys developed MRI visible lesions that were significantly correlated to clinical signs onset. Our longitudinal follow up allows a precise monitoring of lesions and may offer the opportunity to better understand biological and physiological processes underlying the pathology of demyelinating diseases.

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