Abstract #1315

Spatial and temporal characterization of blood brain barrier permeability with disease progression in the NOD-EAE mouse model using MRI and histology

Mohammed Salman Shazeeb¹, Nellwyn Hagan², Xiaoyou Ying¹, and Andrea Edling²

¹DSAR Bioimaging, Sanofi, Framingham, MA, United States, ²Neuroimmunology, Sanofi, Framingham, MA, United States

Blood brain barrier (BBB) dysregulation is one of the earliest signs of multiple sclerosis (MS) and the mechanism underlying BBB breakdown in not completely understood. The non-obese diabetic experimental allergic encephalomyelitis (NOD-EAE) mouse model of secondary progressive MS offers a preclinical tool to understand BBB breakdown and explore potential therapeutics. MRI is capable of quantifying BBB permeability using gadolinium contrast agent. In this study we quantified the spatial and temporal characterization of BBB permeability in NOD-EAE mice with progressing disease using MRI. These quantifying parameters can potentially be used to test the effect of therapeutic agents on BBB breakdown.

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