Abstract #1316

Fluctuations in Ventricle Size during the Progression of Experimental Autoimmune Encephalomyelitis

Laura Boehmert¹, Henning Reimann¹, Stefanie Kox¹, Andreas Pohlmann¹, Thoralf Niendorf^1,2, and Sonia Waiczies¹

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, Berlin, Germany, ²Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, Berlin, Germany

Multiple sclerosis is an autoimmune condition that involves immune cell infiltration through the blood brain barrier, during the initial stages of disease. In the experimental autoimmune encephalomyelitis animal model, we previously observed an increase in ventricle size prior to neurological manifestation. In this study we extended these findings by showing a dynamic fluctuation in ventricle size, with successive re-normalization and re-expansion. Fluctuations in ventricle size commonly ran ahead of clinical relapses and remissions during disease progression. We could identify these findings by following ventricle size for a long period of time (64 days) during the progression of encephalomyelitis.

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