Whole-Brain Ex-Vivo Imaging of Demyelination in the Cuprizone Mouse with mcDESPOT and DTI
Tobias C Wood1, Camilla Simmons1, Joel Torres1, Flavio Dell' Acqua1, Anthony Vernon2, Samuel A Hurley3, Steve CR Williams1, and Diana Cash1
1Neuroimaging, IoPPN, King's College London, London, United Kingdom, 2Basic and Clinical Neuroscience, IoPPN, King's College London, London, United Kingdom, 3FMRIB Centre, University of Oxford, Oxford, United Kingdom
We demonstrate the feasibility of full-brain high-resolution ex-vivo imaging and analysis of demyelination in the Cuprizone mouse model using multi-component DESPOT and DTI. We found evidence of demyelination in the Cerebellum as well as the Corpus Callosum.
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