Abstract #1317

Whole-Brain Ex-Vivo Imaging of Demyelination in the Cuprizone Mouse with mcDESPOT and DTI

Tobias C Wood¹, Camilla Simmons¹, Joel Torres¹, Flavio Dell' Acqua¹, Anthony Vernon², Samuel A Hurley³, Steve CR Williams¹, and Diana Cash¹

¹Neuroimaging, IoPPN, King's College London, London, United Kingdom, ²Basic and Clinical Neuroscience, IoPPN, King's College London, London, United Kingdom, ³FMRIB Centre, University of Oxford, Oxford, United Kingdom

We demonstrate the feasibility of full-brain high-resolution ex-vivo imaging and analysis of demyelination in the Cuprizone mouse model using multi-component DESPOT and DTI. We found evidence of demyelination in the Cerebellum as well as the Corpus Callosum.

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