Abstract #1319

Lesion Distribution Probability in Japanese Macaque Encephalomyelitis: A Comparison to Human Demyelinating Diseases

Ian Tagge¹, Steven Kohama², Dennis Bourdette³, Randy Woltjer³, Scott Wong², and William Rooney¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, United States, ³Neurology, Oregon Health & Science University, Portland, OR, United States

Japanese Macaque Encephalomyelitis bears marked clinical and pathological similarities to multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM), and neuromyelitis optica. Here, we describe lesion topography typical of JME. This represents an important step in not only understanding this disease, but also in making meaningful comparisons to human demyelinating diseases. Animals most commonly presented with lesions in the cerebellum, followed by the brainstem, internal capsule, and upper cervical spinal cord, most similarly to pediatric MS or ADEM. JME is a novel and exciting non-human primate model of MS-like disease that may help elucidate pathomechanisms of human disease.

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