Abstract #1344

Effect of measured Hematocrit value on Glioma grading using Dynamic contrast enhanced derived MR perfusion parameter

Prativa Sahoo¹, Pradeep Kumar Gupta², Ashish Awasthi³, Chandra Mani Pandey³, Rana Patir⁴, Sandeep Vaishya⁵, and Rakesh Kumar Gupta²

¹Healthcare, Philips India ltd, Bangalore, India, ²Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India, ³Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, ⁴Neuorsurgury, Fortis Memorial Research Institute, Gurgaon, India, ⁵Neuorsurgury, Fortis Memorial Research Institute, Lucknow, India

Quantification of DCE-MRI assumes a constant blood hematocrite (Hct ) of 45% for adult human papulation. However Hct varies with disease condition and more with chemotherapy. Correction of the measured signal for blood Hct level is important as blood T1, quantification of contrast agent and arterial input function is dependent on it. Purpose of this study was to investigate the influence of Hct values on glioma grading using DCE-MRI derived perfusion parameters. Study suggest that even though grading of glioma not influenced by Hct values it does affect the kinetic parameters and might be important for monitoring serial assessment of disease progressions.

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