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Abstract #1344

Effect of measured Hematocrit value on Glioma grading using Dynamic contrast enhanced  derived MR perfusion parameter

Prativa Sahoo1, Pradeep Kumar Gupta2, Ashish Awasthi3, Chandra Mani Pandey3, Rana Patir4, Sandeep Vaishya5, and Rakesh Kumar Gupta2

1Healthcare, Philips India ltd, Bangalore, India, 2Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India, 3Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, 4Neuorsurgury, Fortis Memorial Research Institute, Gurgaon, India, 5Neuorsurgury, Fortis Memorial Research Institute, Lucknow, India

Quantification of DCE-MRI assumes a constant blood hematocrite (Hct ) of 45% for adult human papulation. However Hct varies with disease condition and more with chemotherapy. Correction of the measured signal for blood Hct level is important as blood T1, quantification of contrast agent and arterial input function is dependent on it. Purpose of this study was to investigate the influence of Hct values on glioma grading using DCE-MRI derived perfusion parameters. Study suggest that even though grading of glioma not influenced by Hct values it does affect the kinetic parameters and might be important for monitoring serial assessment of disease progressions.

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