Abstract #1349

Optimization of glioma biopsy targeting applying T1-DCE MRI parameter maps – A double-blinded prospective study

Vera Catharina Keil¹, Bogdan Pintea², Gerrit H. Gielen³, Matthias Simon², Juergen Gieseke^1,4, Hans Heinz Schild¹, and Dariusch Reza Hadizadeh¹

¹Department of Radiology, Universitätsklinikum Bonn, Bonn, Germany, ²Clinic for Neurosurgery and Stereotaxy, Universitätsklinikum Bonn, Bonn, Germany, ³Department of Neuropathology, Universitätsklinikum Bonn, Bonn, Germany, ⁴Philips Healthcare, Best, Netherlands

Many centers refrain from implementing semi-quantitative MRI techniques, such as T1w contrast-enhanced MRI (T1-DCE MRI), as a benefit for the patient is questioned. To elucidate if T1-DCE MRI has a benefit, we compared the standard neurosurgical biopsy target selection method (based on T1w contrast-enhanced or FLAIR maps) with a selection based on “hot spots” on K^trans maps in a double-blinded, prospective setting with 27 glioma patients. 87 tissue samples were taken (55 K^trans-based, 32 standard). K^trans-based selection showed a strong tendency to be the more successful targeting method (glioblastoma: n=20/39 vs. n=11/20; p=0.085; WHO III/II: n=12/13 vs. n=6/11; p=0.061).

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