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Abstract #1349

Optimization of glioma biopsy targeting applying T1-DCE MRI parameter maps – A double-blinded prospective study

Vera Catharina Keil1, Bogdan Pintea2, Gerrit H. Gielen3, Matthias Simon2, Juergen Gieseke1,4, Hans Heinz Schild1, and Dariusch Reza Hadizadeh1

1Department of Radiology, Universitätsklinikum Bonn, Bonn, Germany, 2Clinic for Neurosurgery and Stereotaxy, Universitätsklinikum Bonn, Bonn, Germany, 3Department of Neuropathology, Universitätsklinikum Bonn, Bonn, Germany, 4Philips Healthcare, Best, Netherlands

Many centers refrain from implementing semi-quantitative MRI techniques, such as T1w contrast-enhanced MRI (T1-DCE MRI), as a benefit for the patient is questioned. To elucidate if T1-DCE MRI has a benefit, we compared the standard neurosurgical biopsy target selection method (based on T1w contrast-enhanced or FLAIR maps) with a selection based on “hot spots” on Ktrans maps in a double-blinded, prospective setting with 27 glioma patients. 87 tissue samples were taken (55 Ktrans-based, 32 standard). Ktrans-based selection showed a strong tendency to be the more successful targeting method (glioblastoma: n=20/39 vs. n=11/20; p=0.085; WHO III/II: n=12/13 vs. n=6/11; p=0.061).

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