Abstract #1350

Cerebrospinal fluid compression in cerebellum on treatment-naïve MRI might be an early indicator of poor survival in Glioblastoma: A preliminary study

Gavin Hanson¹, Prateek Prasanna¹, Jay Patel¹, Anant Madabhushi¹, and Pallavi Tiwari¹

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Glioblastoma Multiforme (GBM) is very aggressive form of primary brain tumor, and a key part of GBM pathogenesis is the mass effect of the tumor within the ridge container of the brain vault. Mass effect is strongly associated with mortality in patients with GBM. In this work, we seek to quantify the extent of mass effect throughout the brain volume as manifested on MRI to predict patient survival in GBM patients. We use a MRI-driven tensor based morphometry approach, combined with statistical mapping to allow the identification of regions where the deformation associated with mass effect is correlated with overall survival after diagnosis.

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