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Abstract #1362

Apparent diffusion coefficient in preoperative grading of gliomas: a comparison between ultra-high and conventional mono-b value diffusion-weighted MR imaging

YuChuan Hu1, LinFeng Yan1, ZhiCheng Liu1, YingZhi Sun1, DanDan Zheng2, TianYong Xu2, Wen Wang1, and GuangBin Cui1

1Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, China, People's Republic of, 2MR Research China, GE Healthcare China, Beijing, China, People's Republic of

The preoperative grading of gliomas, which is critical for determination of the most appropriate treatment, remains unsatisfactory. As an improved MRI technique, diffusion-weighted imaging (DWI) is considered the most sensitive for early pathological changes and therefore can potentially be useful in evaluating the glioma grades. Recently, apparent diffusion coefficient (ADC) values derived from the high (3000 sec/mm2) b values DWI were reported to improve the diagnostic performance of DWI in differentiating high- from low-grade gliomas5. But a mono-exponential model and relatively lower high-b values were used in this study.We used a tri-component model to calculate ultra-high ADC (ADCuh) in our research, aiming to retrospectively compare the efficacy of ultra-high and conventional mono-b value DWI in the glioma grading.

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