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Abstract #1361

Hybrid PET MRI of brain tumours: spatial relationship of tumour volume in FET PET and 3D MRSI

Jörg Mauler1, Karl-Josef Langen1,2, Andrew A. Maudsley3, Omid Nikoubashman4, Christian Filss1, Gabriele Stoffels1, and N. Jon Shah1,5

1Forschungszentrum Jülich, Jülich, Germany, 2Department of Nuclear Medicine, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3Miller School of Medicine, University of Miami, Miami, FL, United States, 4Department of Neuroradiology, RWTH Aachen University, Aachen, Germany, 5Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany

Gliomas are characterised by an elevated expression of amino acid transporters and cell turnover. The spatial overlap of the corresponding volumes was analysed in 46 subjects, based on O-(2-[18F]fluoroethyl)-L-tyrosine (FET) uptake, measured with PET and by means of the choline to N-acetyl-aspartate (Cho/NAA) ratio, determined by simultaneously acquired, 3D spatially resolved MR spectroscopic imaging data. The overlap between the respective volumes averaged out to (30±23) % with tumour volumes of (14±15) cm3 and (39±28) cm3 in case of FET uptake and increased Cho/NAA-ratio, respectively. Thus the imaging modalities may represent different metabolic properties of gliomas.

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