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Abstract #1360

1H Echo Planar Spectroscopic Imaging of 2-hydroxyglutarate in Gliomas at 7T in vivo

Zhongxu An1, Sandeep Ganji1, Vivek Tiwari1, Marco C. Pinho1,2, Edward Pan3,4,5, Bruce E. Mickey3,5,6, Elizabeth A. Maher3,4,6,7, and Changho Choi1,2,3

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 4Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, United States, 5Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, 6Annette Strauss Center for Neuro-Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 7Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States

2-hydroxyglutarate (2HG) is the first imaging biomarker for IDH-mutated gliomas. High-spatial resolution spectroscopic imaging of 2HG is clinically important. We propose a new EPSI read-out scheme to overcome the conventional limitation of EPSI spectral bandwidth at high field. With SNR and linewidth benefit at 7T, we demonstrated the in vivo feasibility of this new EPSI method in mapping of 2HG and other important brain metabolites in normal subject and glioma patients at 7T.

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