Abstract #1359

In Vivo Detection of 2-Hydroxyglutarate in Low-Grade Glioma Patients

Elizabeth D Phillips¹, Llewellyn E Jalbert¹, Yan Li¹, Marisa M Lafontaine¹, and Sarah J Nelson¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

While the feasibility of utilizing 2HG as a magnetic resonance biomarker has been established ex vivo, several different approaches to obtaining in vivo data have been presented. This project aims to assess the concordance of 2HG detection using asymmetric echo PRESS MRSI with IDH1_R132H mutation as identified via antibody staining in patients with LGG, and to investigate the relationship of other metabolites detected with this sequence to IDH status. Further research is required before routine clinical implementation of these methods is recommended.

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