Abstract #1358

Bayesian Estimation of Microstructural Parameters in Glioma Patients and Comparison with Genetic Analysis

Elias Kellner¹, Marco Reisert¹, Ori Staszewski², Bibek Dhital¹, Valerij G Kiselev¹, Karl Egger³, Horst Urbach³, and Irina Mader³

¹Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, ²Freiburg, Germany, ³Department of Neuroradiology, University Medical Center Freiburg, Freiburg, Germany

In a recent study, we proposed a method for fast and direct estimation of mictrostructural tissue parameters such as intra/extraaxonal volume fraction and diffusivities based on multishell DWI. In this study, we report the first method application to human gliomas and demonstrate connections of microstructural parameters with genetic markers IDH and 1p19q in a group of 32 patients.

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