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Abstract #1358

Bayesian Estimation of Microstructural Parameters in Glioma Patients and Comparison with Genetic Analysis

Elias Kellner1, Marco Reisert1, Ori Staszewski2, Bibek Dhital1, Valerij G Kiselev1, Karl Egger3, Horst Urbach3, and Irina Mader3

1Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2Freiburg, Germany, 3Department of Neuroradiology, University Medical Center Freiburg, Freiburg, Germany

In a recent study, we proposed a method for fast and direct estimation of mictrostructural tissue parameters such as intra/extraaxonal volume fraction and diffusivities based on multishell DWI. In this study, we report the first method application to human gliomas and demonstrate connections of microstructural parameters with genetic markers IDH and 1p19q in a group of 32 patients.

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