Elias Kellner1, Marco Reisert1, Ori Staszewski2, Bibek Dhital1, Valerij G Kiselev1, Karl Egger3, Horst Urbach3, and Irina Mader3
1Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2Freiburg, Germany, 3Department of Neuroradiology, University Medical Center Freiburg, Freiburg, Germany
In a recent study, we proposed a method for fast and direct estimation of
mictrostructural tissue parameters such as intra/extraaxonal volume fraction
and diffusivities based on multishell DWI. In this study, we report the first
method application to human gliomas and demonstrate connections of
microstructural parameters with genetic markers IDH and 1p19q in a group of 32
patients.
