Automatic normalization of DCE-MRI derived cerebral blood volume (CBV) may improve glioma grading
Prativa Sahoo1, Indrajit Saha2, and Rakesh Kumar Gupta3
1Healthcare, Philips India ltd, Bangalore, India, 2Philips Healthcare, Philips India ltd, Gurgaon, India, 3Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India
DCE-MRI derived relative blood volume (rCBV) correlates excellently with grade of glioma. Traditionally rCBV is calculated by dividing CBV value of tumor region with the CBV value from the corresponding contra-lateral region by identifying and placing region of interest (ROI). This technique is tedious needs user expertise. The main aim of this study was to develop an automatic method to normalize CBV so that the user-induced biasness in glioma grading due to ROI placement can be reduced. Normalized CBV provides a better contrast between tumor and normal region
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