Abstract #1371

The Value of CBF Combined With Temporal Information in Grading High-Grade Astrocytomas: A Multi-Inversion-Time Arterial-Spin-Labeling Magnetic Resonance Study

Shuang Yang¹, Tianyi Qian², Jianwei Xiang¹, Yingchao Liu³, Fei Gao¹, Peng Zhao³, Josef Pfeuffer⁴, Guangbin Wang¹, and Bin Zhao¹

¹Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, People's Republic of, ²MR Collaborations NE Asia, Siemens Healthcare, Beijing, China, People's Republic of, ³Shandong provincial Hospital, Shandong University, Jinan, China, People's Republic of, ⁴Application Development, Siemens Healthcare, Erlangen, Germany

This study aimed to demonstrate the feasibility of multi-inversion-time arterial spin labeling (mTI-ASL) for differentiating between WHO III and WHO IV grade astrocytomas, as well as the added value of bolus arrival time (BAT) information in evaluating tumor perfusion. In the first part of this study, we evaluated the reproducibility of mTI-ASL in healthy subjects, and then mTI-ASL was used to evaluate 45 astrocytoma patients. There was no major variation between two consecutive mTI-ASL measurements in healthy volunteers. Furthermore, mTI-ASL provided valuable information for the classification of astrocytomas, while BAT added relevant information for grading by estimating the temporal dynamics of local tumor-mass perfusion.

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