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Abstract #1371

The Value of CBF Combined With Temporal Information in Grading High-Grade Astrocytomas: A Multi-Inversion-Time Arterial-Spin-Labeling Magnetic Resonance Study

Shuang Yang1, Tianyi Qian2, Jianwei Xiang1, Yingchao Liu3, Fei Gao1, Peng Zhao3, Josef Pfeuffer4, Guangbin Wang1, and Bin Zhao1

1Shandong Medical Imaging Research Institute, Shandong University, Jinan, China, People's Republic of, 2MR Collaborations NE Asia, Siemens Healthcare, Beijing, China, People's Republic of, 3Shandong provincial Hospital, Shandong University, Jinan, China, People's Republic of, 4Application Development, Siemens Healthcare, Erlangen, Germany

This study aimed to demonstrate the feasibility of multi-inversion-time arterial spin labeling (mTI-ASL) for differentiating between WHO III and WHO IV grade astrocytomas, as well as the added value of bolus arrival time (BAT) information in evaluating tumor perfusion. In the first part of this study, we evaluated the reproducibility of mTI-ASL in healthy subjects, and then mTI-ASL was used to evaluate 45 astrocytoma patients. There was no major variation between two consecutive mTI-ASL measurements in healthy volunteers. Furthermore, mTI-ASL provided valuable information for the classification of astrocytomas, while BAT added relevant information for grading by estimating the temporal dynamics of local tumor-mass perfusion.

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