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Abstract #1372

The effect of prophylactic cranial irradiation on brain diffusion and magnetization transfer

Mary A McLean1, Nicola L Ainsworth1,2, Anna M Brown1, Susan V Harden2, and John R Griffiths1

1CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 2Oncology, Addenbrooke's Hospital, Cambridge, United Kingdom

We investigated the effect of prophylactic cranial irradiation (PCI: 25 Gy in 10 fractions) on brain MRI at 3T. Six patients with small cell lung cancer were scanned at 4-month intervals: at diagnosis, following chemotherapy, and following PCI. Paired t-tests before and after PCI in right frontal white matter showed increased ADC and decreased FA and MTR following treatment. However, the parameters did not differ significantly from the scan at diagnosis, and other brain regions showed no significant changes on repeated-measures ANOVA. These observations are consistent with previous reports of more marked changes following higher-dose radiotherapy treatment.

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