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Abstract #1373

Differentiation of Glioblastoma Multiforme and Primary Cerebral Lymphoma with Diffusion-Weighted MR Imaging

Ching Chung Ko1,2, Yu Chang Lee3, Ming Hong Tai2, Tai Yuan Chen1, Yu Ting Kuo1, and Jeon Hor Chen3,4

1Department of Medical Imaging, Chi Mei Medical Center, Tainan, Taiwan, 2Institute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan, 3Department of Radiology, I-Shou University and Eda Hospital, Kaohsiung, Taiwan, 4Center for Functional Onco-Imaging, University of California, Irvine, CA, United States

Atypical glioblastoma multiformes (GBMs) with solid enhancing tumor and without visible necrosis may mimic primary cerebral lymphomas (PCLs), and atypical PCLs with visible necrosis may mimic GBMs. This study aimed to differentiate these two brain tumors using qualitative DWI signals and quantitative ADC values acquired in tumoral necrosis, the most enhanced tumor area, and the peritumoral edema. The results showed GBMs tended to have significantly higher ADC in the enhanced tumor area, and lower ADC in the peritumoral edema area than PCLs.

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