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Abstract #1381

Evaluation of vascular permeability in gliomas by using parameter K2 from dynamic susceptibility contrast data-sets and histogram analysis.

Toshiaki Taoka1, Hisashi Kawai1, Toshiki Nakane1, Toshiteru Miyasaka2, and Shinji Naganawa1

1Radiology, Nagoya University, Nagoya, Japan, 2Radiology, Nara Medical University, Kashihara, Japan

Permeability images can provide additional information to perfusion images in the clinical practice of brain tumors. However, permeability imaging by dynamic contrast enhancement methods requires a long acquisition time. K2 is an index that represents permeability and can be calculated from the dataset of perfusion images with the dynamic susceptibility contrast method, which requires a short acquisition time. In the current study, we calculated K2 for various grades of gliomas and found that K2 showed a significantly higher 20th percentile value in Grade IV compared to Grade III gliomas, providing useful information for grading of gliomas.

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