Abstract #1382

Characterising tumour progression and pseudoprogression on preoperative multimodal MRI imaging

Jiun-Lin Yan^1,2,3, Anouk van der Hoorn⁴, Timothy J Larkin⁵, Natalie Rosella Boonzaier⁵, Tomasz Matys⁶, and Stephen J Price⁵

¹Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom, ²Department of neurosurgery, Chang Gung Memorial Hospital, Keelung, Taiwan, ³Department of neurosurgery, Chang Gung University College of Medicine, Taoyuan, Taiwan, ⁴Department of radiology (EB44), University of Groningen, Groningen, Netherlands, ⁵Brain tumour imaging laboratory, University of Cambridge, Cambridge, United Kingdom, ⁶Department of radiology, University of Cambridge, Cambridge, United Kingdom

Glioblastoma is a highly malignant tumor which recur mostly within 2 cm around the resected contrast enhancement. However, it is difficult to identify tumor invasiveness pre-surgically especially in non-enhanced area. Thus, we aimed to identify possible imaging characteristics preoperatively using multimodal MR techniques in the peritumoral regions that eventually leads to tumor recurrence or progression. Our study showed lower isotorpic p, anisotopic q and ADC for progression compared to non-progression regions. In addition, MRS showed a not statistically significant trend of higher choline/NAA, higher choline and lower NAA in these progression area.

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