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Abstract #1382

Characterising tumour progression and pseudoprogression on preoperative multimodal MRI imaging

Jiun-Lin Yan1,2,3, Anouk van der Hoorn4, Timothy J Larkin5, Natalie Rosella Boonzaier5, Tomasz Matys6, and Stephen J Price5

1Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom, 2Department of neurosurgery, Chang Gung Memorial Hospital, Keelung, Taiwan, 3Department of neurosurgery, Chang Gung University College of Medicine, Taoyuan, Taiwan, 4Department of radiology (EB44), University of Groningen, Groningen, Netherlands, 5Brain tumour imaging laboratory, University of Cambridge, Cambridge, United Kingdom, 6Department of radiology, University of Cambridge, Cambridge, United Kingdom

Glioblastoma is a highly malignant tumor which recur mostly within 2 cm around the resected contrast enhancement. However, it is difficult to identify tumor invasiveness pre-surgically especially in non-enhanced area. Thus, we aimed to identify possible imaging characteristics preoperatively using multimodal MR techniques in the peritumoral regions that eventually leads to tumor recurrence or progression. Our study showed lower isotorpic p, anisotopic q and ADC for progression compared to non-progression regions. In addition, MRS showed a not statistically significant trend of higher choline/NAA, higher choline and lower NAA in these progression area.

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