Abstract #1392

7 T MRS Investigation of the Glutamatergic System in Depression

Clark Lemke^1,2, Charles Masaki¹, Uzay Emir², Beata Godlewska¹, and Phil Cowen¹

¹Department of Psychiatry, University of Oxford, Oxford, United Kingdom, ²FMRIB, University of Oxford, Oxford, United Kingdom

The glutamatergic system is believed to play a significant role in depression pathology. While many magnetic resonance spectroscopy (MRS) studies of depression have targeted the glutamatergic system, they have all been performed at magnetic field strengths of 4 T or lower – limiting their ability to differentiate between glutamate and glutamine. This study presents the first investigation of the glutamatergic system in depressed subjects at 7 T. Voxels were placed in the occipital cortex, anterior cingulate cortex, and putamen and metabolites were quantified using LCModel. Results indicate a significant decrease in glutamate in the occipital cortex and a significant increase of glutamine in the putamen.

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