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Abstract #1391

Corpus callosum morphology and microstructure in late-life depression

Louise Emsell1,2, Christopher Adamson3, Filip Bouckaert1, Thibo Billiet2, Daan Christiaens4, Francois-Laurent De Winter1, Marc Seal3, Pascal Sienaert1, Stefan Sunaert2, and Mathieu Vandenbulcke1

1UPC-KU Leuven, Leuven, Belgium, 2Translational MRI, KU Leuven, Leuven, Belgium, 3Developmental Imaging, Murdoch Childrens Research Institute, Melbourne, Australia, 4ESAT/PSI, KU Leuven, Leuven, Belgium

Differences in corpus callosum (CC) morphology and microstructure have been implicated in late-life depression (LLD), however it is not clear to what extent microstructural alterations result from partial volume effects arising from macrostructural differences. Here we combined T1 morphological measures (thickness and area) with multiple diffusion MRI measures (fractional anisotropy, radial diffusivity and apparent fibre density (AFD)) to investigate the mid-sagittal CC in 51 patients with LLD and 52 healthy controls. LLD was associated with subtle, independent regional macro- (reduced area) and microstructural (reduced AFD) differences in the corpus callosum, unrelated to depression subtype or illness severity.

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