Abstract #1390

Neural basis of the association between anxiety and depression symptoms in unmedicated major depressive disorder patients

Cancan He¹, Liang Gong¹, Chunming Xie¹, and Yingying Yin¹

¹Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China, People's Republic of

In this study, 75 unmedicated MDD patients and 42 cognitively normal(CN) subjects underwent the resting-state functional magnetic resonance imaging (R-fMRI) scan. We found that the MDD patients showed dysfunctional connectivity in wide-spread amygdala functional connectivity(AFC) networks, and these abnormal amygdala connectivity were influenced the trait property in MDD. Further analysis revealed that MDD patients with lower HAMA scores showed milder depressive symptom and greater AFC strength while MDD patients with higher HAMA scores showed more severe depressive symptom and lower AFC strength. Beyond that, the mediation effects of AFC networks on the association between anxiety and depression all reached a significant level in MDD patients.

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