Abstract #1394

Brain grey matter volume alterations in treatment resistant depression -- systematic review and meta-analysis

Xin Xu¹, Jia Liu², and Qiyong Gong²

¹Department of Psychiatry, Huaxi MR Research Center(HMRRC),West China Hospital of Sichuan Universityl, Chengdu, China, People's Republic of, ²Department of Radiology, Huaxi MR Research Center(HMRRC),West China Hospital of Sichuan Universityl, Chengdu, China, People's Republic of

To our knowledge, this is the first study to pool VBM studies for a meta-analysis of grey matter differences among the treatment-sensitive depression (TSD), treatment-resistant depression (TRD) and health control (HC) by using anisotropic effect-size signed differential mapping (AES-SDM). Although both TRD and TSD groups showed abnormal grey matter in frontal and temporal cortex, the exact brain regions were mostly different in both groups except the left inferior frontal gyrus (IFG). Furthermore, grey matter volume reductions in the bilateral cingulate cortex were only observed in the TRD group.

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