Abstract #1397

Gray and white matter volume changes and the correlation with depression and anxiety in obese patients revealed by voxel-based morphometry

Jun-Cheng Weng^1,2, Chi-Ju Lai¹, Hse-Huang Chao³, Ming-Chou Ho⁴, and Vincent Chin-Hung Chen⁵

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan, ³Tiawan Center for Metabolic and Bariatric Surgery, Jen-Ai Hospital, Taichung, Taiwan, ⁴Department of Psychology, Chung Shan Medical University, Taichung, Taiwan, ⁵Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan

Obesity is an important health issue in modern society. The prevalence of obesity has been increasing in these years and morbid obesity is related to cardiovascular disease and overall mortality. Past reviews regarded binge eating as a manifestation of dysfunctional reward system and disinhibition. Some authors considered binge eating as a kind of addiction. Recent study demonstrated the more extensive involvement of brain pathways other than reward system. The mechanism of change is not clear. There is scanty of research regarding correlation between change of activation pattern in brain areas in functional MRI, binge eating and psychiatric illness. To gain insight into the correlation of physiological alteration and psychiatric illness and to develop subsequent detectable biomarker are crucial. The goal of our study was to investigate the morphological changes in gray and white matter between obese patients and healthy subjects using voxel-based morphometry (VBM). Our results suggested the changes of the volume in the brain structures may closely linked to the symptom and behavior of obese patients. Apply these novel markers to monitoring and improving cormorbid psychiatric illness will be an essential part of multidiscipline integral care for obese patients.

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