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Abstract #1398

MR Imaging of Major Depressive Disorder: Effects of Sertraline Treatment

Hung-Wen Kao1,2, Chien-Yuan Eddy Lin3,4, Chu-Chung Huang5, Yi-Hui Lin6, I-Ling Chung7, Yu-Chuan Chang8, Guo-Shu Huang1, and Ching-Po Lin2,5,6,9

1Department of radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, 2Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 3GE Healthcare, Taipei, Taiwan, 4GE Healthcare MR Research China, Beijing, China, People's Republic of, 5Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan, 6Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, 7Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan, 8Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 9Brain Research Center, National Yang-Ming University, Taipei, Taiwan

We hypothesized that a predictive MR imaging model of sertraline treatment could be established to help treatment planning for patients with Major depressive disorder (MDD). The voxel-based morphometry analysis showed increase volume of the lingual and occipital gyri in patients with MDD as compared with those in healthy controls and the size of the occipital gyrus decreased after 6-week treatment of sertraline. The findings support that patients with MDD might have a functional abnormality of visual areas and antidepressant treatment might shift the abnormal activity in the antidepressant-susceptible brain region to a normal level.

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