Abstract #1399

Simultaneous Real-time fMRI and EEG Neurofeedback for Emotion Regulation Training in Depressed Patients

Vadim Zotev¹, Raquel Phillips¹, Masaya Misaki¹, Ahmad Mayeli^1,2, and Jerzy Bodurka^1,3

¹Laureate Institute for Brain Research, Tulsa, OK, United States, ²Electrical and Computer Engineering, University of Oklahoma, Tulsa, OK, United States, ³College of Engineering, University of Oklahoma, Tulsa, OK, United States

We have performed an exploratory study of emotion self-regulation training in major depressive disorder (MDD) patients using simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf). MDD patients learned to upregulate two fMRI and two EEG target measures, relevant to MDD, using rtfMRI-EEG-nf during a happy emotion induction task. The target measures included fMRI activities of the left amygdala and left rACC, as well as frontal EEG asymmetries in the alpha and high-beta bands. Our results demonstrate that MDD patients can learn to successfully upregulate all four measures simultaneously. These findings may lead to development of more efficient neurotherapies for MDD.

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