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Abstract #1403

Measuring Longitudinal Changes in Cerebral Blood Flow and Blood Volume in Neonates with the Intravoxel Incoherent Motion Method

Alex Cerjanic1,2, Ellen Grant3, Borjan Gagoski3, Marie Drottar3, Thea Francel3, Alana Matos3, Clarissa Carruthers3, Jonathan Litt4, Ryan Larsen2, and Bradley P Sutton1,2

1Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Boston Children's Hospital, Boston, MA, United States, 4Beth Israel Deaconness, Boston, MA, United States

Diffusion weighted MRI was used on a cohort of 5 neonates to quantify cerebral blood flow and cerebral blood volume through the intravoxel incoherent motion (IVIM) model. Data at two time points, approximately 2 weeks and 14 weeks, were obtained. The obtained pseudodiffusion coefficient and the perfusion fractions were examined across white matter, gray matter, and the basal ganglia for all subjects. A significant longitudinal decrease in the perfusion fraction (-1.12%) was noted in the white matter between 2 and 14 weeks while the static diffusion coefficient of tissue decreased for all tissue classes between those time points.

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