Abstract #1410

Synchronous Aberrant Cerebellar and Opercular Development in Fetuses and Neonates with Congenital Heart Disease (CHD)

Alexandra Wong¹, Thomas Chavez², Jodie Votava-Smith², David Miller², Hollie Lai², Sylvia delCastillo², Lisa Paquette³, and Ashok Panigrahy²

¹New York Medical College, Valhalla, NY, United States, ²Los Angeles, CA, United States, ³University of Southern California, Los Angeles, CA, United States

Children with congenital heart disease (CHD) demonstrate problems with multi-domain cognitive control of unknown etiology. Cingo-opercular and cerebellar brain networks are known to be critical in multi-domain cognitive control including language function. Little is known about the comparative structural growth trajectories of the cerebellum and operculum in CHD patients. To our knowledge, the literature only describes fetal opercular measurements by ultrasound.1 And, data from the neonatal period is scant, gathered from children suffering from “temporary neurologic dysfunction” or from cadaveric specimens.2,3 The fetal cerebellum has been described on MRI mostly in terms of its volume4,5 or area,6 although a few have used linear measurements as the basis of their fetal cerebellar growth illustration.7,8,9

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