Disrupted Resting State Connectivity in Term Neonates with Complex CHD
Vincent Kyu Lee1,2, Vincent Schmithorst2, Shahida Sulaiman1, Lisa Paquette3, Jodie Votava-Smith3, and Ashok Panigrahy1,2
1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, 3Cardiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States
The last trimester
of brain development in fetuses with complex congenital heart disease (CHD) is
abnormal. In this study, we use ICA
analysis on resting BOLD of CHD patients to characterize the neuronal activity and
compare it to healthy controls. A total
of 117 BOLD images from CHD and healthy neonates were analyzed using Temporal concatenation
ICA with MELODIC FSL. Both CHDs and
Controls exhibited common RSNs, but CHDs lacked additional RSNs observed in
controls. CHD group exhibited ICAs with
less complexity than controls, which maybed due to global brain dysmaturation
with disruption of cortical to subcortical connectivity.
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