Abstract #1411

Disrupted Resting State Connectivity in Term Neonates with Complex CHD

Vincent Kyu Lee^1,2, Vincent Schmithorst², Shahida Sulaiman¹, Lisa Paquette³, Jodie Votava-Smith³, and Ashok Panigrahy^1,2

¹Radiology, University of Pittsburgh, Pittsburgh, PA, United States, ²Radiology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States, ³Cardiology, Children's Hospital of Los Angeles, Los Angeles, CA, United States

The last trimester of brain development in fetuses with complex congenital heart disease (CHD) is abnormal. In this study, we use ICA analysis on resting BOLD of CHD patients to characterize the neuronal activity and compare it to healthy controls. A total of 117 BOLD images from CHD and healthy neonates were analyzed using Temporal concatenation ICA with MELODIC FSL. Both CHDs and Controls exhibited common RSNs, but CHDs lacked additional RSNs observed in controls. CHD group exhibited ICAs with less complexity than controls, which maybed due to global brain dysmaturation with disruption of cortical to subcortical connectivity.

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